Secremax, SecreFlo (Repligen Corp)

Secremax, SecreFlo (Repligen Corp) - General Information

This drug is the synthetic form of natural secretin. It is prepared using solid phase peptide synthesis. Secremax, SecreFlo (Repligen Corp) is a peptide hormone produced in the S cells of the duodenum. Its main effect is to regulate the pH of the small intestine’s contents through the control of gastric acid secretion and buffering with bicarbonate. It was the first hormone to be discovered.

Pharmacology of Secremax, SecreFlo (Repligen Corp)

Used in the diagnosis of pancreatic dysfunction or gastrinoma (stomach cancer), secretin is a hormone produced in the S cells of the duodenum in response to low local pH. It stimulates the secretion of bicarbonate from bicarbonate producing organs(liver, pancreas, Brunner's glands) when the pH drops below a set value. This helps neutralize the gastric acid entering the duodenum from the stomach. It also inhibits acid secretion from the stomach by reducing gastrin release from the G cells of the stomach.

Secremax, SecreFlo (Repligen Corp) for patients

Secremax, SecreFlo (Repligen Corp) Interactions

Drug/Laboratory Test Interaction: The concomitant use of anticholinergic agents may make patients hyporesponsive, i.e. may produce a false positive result.

Secremax, SecreFlo (Repligen Corp) Contraindications

Patients suffering from acute pancreatitis should not receive SecreFlo™ until the acute episode has subsided.

Additional information about Secremax, SecreFlo (Repligen Corp)

Secremax, SecreFlo (Repligen Corp) Indication: For diagnosis of pancreatic exocrine dysfunction and gastrinoma
Mechanism Of Action: Secremax, SecreFlo (Repligen Corp) binds to the secretin receptor found on the lining of S cells in the duodenum and G cells in the stomach. Binding leads to the secrection of bicarbonate or the reduction of the secretion of gastrin. Properly functioning organs (duodenum, pancreas and stomach) should be responsive to this hormone
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Secretin
Synonyms: Secremax, SecreFlo
Drug Category: Diagnostic Agents
Drug Type: Biotech; Approved; Investigational

Other Brand Names containing Secretin: Secremax, SecreFlo (Repligen Corp); SecreFlo;
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Secremax, SecreFlo (Repligen Corp): Injection, powder, lyophilized, for solution Intravenous
Chemical IUPAC Name: Not Available
Chemical Formula: C130H219N43O42
Secretin on Wikipedia: https://en.wikipedia.org/wiki/Secretin
Organisms Affected: Humans and other mammals